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.modal-content > div{font-size:1.3rem;line-height:1.5em;margin:0 0 0.5em 0;}@media screen and (max-width:575.98px){.modal-dialog{overflow-y:scroll;}.modal .modal-content > div{font-size:1.15rem;line-height:1.5em;}}.modal .modal-content > div > p{margin:0 0 0.5em 0;}#externallinksModal .modal-content > div > p{margin:0;font-size:1.15rem;}@media (min-width:769px){#externallinksModal .modal-content > div > p{text-align:center;}}#externallinksModal .modal-content h3{text-align:center;color:#4d4084;font-size:1.35rem;}.modal .modal-dialog .modal-content-message{margin:1.5em 0 2em 0;text-align:center;}#externallinksModal .modal-dialog .modal-content-message{font-size:1.15rem;}.modal .two-button-container{padding:0;display:flex;}.modal .two-button-container .button{display:block;padding:0.8rem 0.75rem;font-size:1.125rem;line-height:1.375rem;text-align:center;font-weight:bold;background:#4d4084;border:4px solid #4d4084;color:#ffffff;transition:all 350ms ease;text-decoration:none;}@media (min-width:769px){.modal .two-button-container .button{max-width:50%;flex-basis:50%;margin:0 15px;}}.modal .two-button-container .button:hover{background:#ffffff;color:#4d4084;text-decoration:underline;}@media screen and (max-width:768.98px){.modal .two-button-container{flex-direction:column;}.modal .two-button-container .button:not(:last-of-type){margin-bottom:25px;}}.alnylam_connect_container{font-size:min(0.9rem,5vw);line-height:1em;padding:0.8em 0 0.6em 0;text-align:right;background-color:#ced5da;}@media screen and (max-width:768.98px){.alnylam_connect_container{font-size:min(0.85rem,5vw);}}#logoset-container{max-width:600px;width:80%;padding:0 40px;margin:-1.5rem auto 0;}@media screen and (max-width:575.98px){#logoset-container{width:100%;padding:0;}}.update_info .news{border:solid 1px #4d4084;padding:30px;}.update_info .news h2{font-size:1.25rem;line-height:1em;margin:0 0 0.875rem 0;font-weight:normal;color:#4d4084;}.update_info .news div{font-size:1rem;line-height:1.4rem;}.update_info .news .news_main{display:table;}.update_info .news div.line{display:flex;justify-content:flex-start;align-items:flex-start;margin-bottom:0.5rem;}.update_info .news div.line:last-child{margin-bottom:0;}.update_info .news div.line > div:first-child{white-space:nowrap;padding-right:1em;flex-shrink:0;flex-grow:0;}.update_info .news div.line:first-child div{padding-top:0;}.update_info .news div.line div{display:table-cell;line-height:1.4em;}@media (min-width:769px){.update_info .news .news_main_wrap{padding-right:15px;min-height:80px;max-height:200px;overflow-y:scroll;}.update_info .news div.news_main_wrap::-webkit-scrollbar{width:10px;}.update_info .news div.news_main_wrap::-webkit-scrollbar-thumb{background-color:#e9e9e7;border-radius:10px;}}@media screen and (max-width:768.98px){.update_info .news{padding:15px;}.update_info .news h2{font-weight:bold;font-size:1rem;margin:0;}.update_info .news div.line div{display:block;}.update_info .news div.line div:first-child{font-weight:bold;padding:0.8em 0 0 0;}.update_info .news div.line div:last-child{padding:0.1em 0 0 1em;}}.banner_container{display:flex;width:100%;}.banner_container > a{display:flex;flex-direction:column;justify-content:space-between;flex-basis:50%;}.banner_container > a > picture{display:inline-block;margin-top:0.5rem;}.banner_container > a > picture > img{width:100%;border:1px solid #4d4084;box-shadow:5px 5px 5px -3px rgba(0,0,0,0.1);}@media (min-width:576px){.banner_container > a:first-of-type{margin-right:1rem;}.banner_container > a:last-of-type{margin-left:1rem;}}@media screen and (max-width:575.98px){.banner_container{flex-direction:column;}.banner_container > a:last-of-type{margin-top:3rem;}}section{margin-bottom:3rem;}section.no_margin_bottom{margin-bottom:0;}section.explanation_section{margin:2rem 0 0 0;}.page_info_section .page_info_category{display:none;}.page_info_section .page_info_title{text-align:center;color:#e7004c;font-size:1.8rem;line-height:1.4em;}.page_info_section .page_info_group_name + .page_info_title{margin-top:0;}.page_info_section .page_info_group_name{text-align:center;color:#e7004c;font-size:1rem;margin-bottom:0;}.page_info_section .page_info_group_name::after{content:"\0FF1A";}.message_section h2{text-align:center;color:#4d4084;font-size:1.65rem;line-height:1.5em;}.message_section h2 > span{display:block;}@media screen and (max-width:575.98px){.message_section h2{font-size:1.3rem;}}.mt{margin-top:1rem !important;}.no_maker,.explicit_maker{list-style:none;padding:0;margin:0;}p + .explicit_maker{margin-top:1rem;}p + .explicit_maker.no_mt{margin-top:0;}.explicit_maker > li{display:flex;align-items:flex-start;justify-content:flex-start;}.explicit_maker > li > *:first-child{flex-shrink:0;flex-grow:0;margin-right:0.3em;}.explicit_maker > li > *:last-child{flex-grow:1;}.basic_annotation{display:grid;grid-template-columns:fit-content(1ch) auto;font-size:0.85rem;margin:1em 0 0 0;align-items:start;font-size:0.85rem;line-height:1.4em;}.basic_annotation.no_mt{margin:0;}p + .basic_annotation.no_mt{margin:0.3rem 0 0 0;}.basic_annotation > dt{white-space:nowrap;margin:0 0.3em 0 0;text-align:right;}.basic_annotation > dd{margin:0;}#characteristic_list > ol > li{border-top:1px solid #acacad;}#characteristic_list > ol > li:last-of-type{border-bottom:1px solid #acacad;}#characteristic_list > ol > li > *:first-child{font-weight:bold;text-align:center;font-size:3.45rem;line-height:1em;width:1em;padding-left:0.3rem;color:#4d4084;}#characteristic_list > ol > li:nth-of-type(3) > *:first-child{height:100%;}#characteristic_list > ol > li > *:last-child{font-size:1.15rem;font-weight:bold;line-height:1.5em;display:flex;align-items:center;}#characteristic_list > ol ol > li{font-weight:normal;margin-top:0.3rem;}@media (min-width:576px){#characteristic_list > ol > li > *{padding:1.3rem 0;}#characteristic_list > ol > li > *:last-child{min-height:3.45rem;}}@media screen and (max-width:575.98px){#characteristic_list > ol > li{flex-direction:column;align-items:center;}#characteristic_list > ol > li > *:first-child{margin:1rem 0 0 0;padding:0;}#characteristic_list > ol > li > *:last-child{margin:0.5rem 0 1rem 0;}}.bottom_navigation_container{display:flex;justify-content:space-between;padding-top:1rem;width:100%;}@media (min-width:576px){.bottom_navigation_container.bottom_navigation_container__next_only{justify-content:flex-end;}}.bottom_navigation_container a{display:flex;align-items:center;text-decoration:none;font-size:1.1rem;line-height:1em;font-weight:bold;}.bottom_navigation_container a .with_link_category{display:table;flex-direction:column;width:10px;}.bottom_navigation_container a .with_link_category *:first-child{display:table-row;font-size:0.85rem;white-space:nowrap;}.bottom_navigation_container a .with_link_category *:last-child{display:table-row;text-align-last:justify;text-justify:inter-ideograph;}.bottom_navigation_container .link_prev a::before,.bottom_navigation_container .link_next a::after{content:"";display:block;width:2.1rem;height:1.1rem;opacity:1;margin-top:-3px;flex-shrink:0;}.bottom_navigation_container .link_prev a:hover::after,.bottom_navigation_container .link_next a:hover::after{opacity:0.6;}.bottom_navigation_container .link_prev a::before{margin-right:0.8rem;background:no-repeat center/contain url("/themes/amvuttra_jp/assets/image/arrow_left.svg");}.bottom_navigation_container .link_next a::after{margin-left:0.8rem;background:no-repeat center/contain url("/themes/amvuttra_jp/assets/image/arrow_right.svg");}@media screen and (max-width:575.98px){.bottom_navigation_container{flex-direction:column;}.bottom_navigation_container .link_next{display:flex;justify-content:flex-end;}.bottom_navigation_container > div:nth-of-type(2){margin-top:2rem;}.bottom_navigation_container > div{font-size:0.9rem;}.bottom_navigation_container .link_prev a::before{margin-right:0.4rem;}.bottom_navigation_container .link_next a::after{margin-left:0.4rem;}.bottom_navigation_container .link_prev a::before,.bottom_navigation_container .link_next a::after{width:1.6rem;}}.content_section h2{font-size:1.4rem;color:#4d4084;margin:0 0 0.6em 0;}@media screen and (max-width:575.98px){.content_section h2{font-size:1.25rem;}}.message_section p,.content_section p{margin:0;}.content_section p + p{margin-top:1rem;}figure{padding:2rem 0;margin-left:auto;margin-right:auto;}figure > picture{display:flex;justify-content:center;}figure > picture > img{width:100%;margin:0 1rem;}#moa_detail .explicit_maker > li > *:first-child{color:#e7004c;}#moa_detail figure img{max-width:800px;}.embed-responsive{position:relative;width:100%;margin:0 auto;}h2 + .embed-responsive{margin-top:1.5rem;}.embed-responsive-16by9{aspect-ratio:16 / 9;}.embed-responsive-max800{max-width:800px;}.embed-responsive iframe,.embed-responsive embed,.embed-responsive object .embed-responsive video{position:absolute;top:0;bottom:0;left:0;width:100%;height:100%;border:none;}.note{font-size:0.85rem;line-height:1.4em;}@media screen and (max-width:575.98px){.note{font-size:0.8rem;}}.align_right{text-align:right;}.align_center{text-align:center;}.margin_top,.content_section p.margin_top{margin-top:1rem;}.di_section *{}.di_section > div > .explicit_maker > li > div:first-child,.di_section > div > .explicit_maker > li > div:last-child > h2{font-weight:bold;font-size:1.2rem;color:#4d4084;margin-bottom:0.5rem;}.di_section h3,.di_section .with_title{font-size:1rem;font-weight:bold;margin:0;}.di_section table{border-bottom-width:2px;margin-top:0.2rem;}.di_section tr > *:first-child{border-left:none;}.di_section tr > *:last-child{border-right:none;}.di_section table > *:first-child > tr:first-child > *{border-top-width:2px;}.di_section table th,.di_section table td{padding:0.8rem 0.6rem 0.6rem;text-align:center;}.di_section table th{color:#4d4084;font-weight:bold;vertical-align:top;}.di_section table{width:100%;}.di_section .explicit_maker > li:not(:first-of-type){margin-top:0.5rem;}.di_section .explicit_maker > li.with_table + li.with_table{margin-top:1rem;}.di_section .explicit_maker > li > div:first-of-type{font-weight:bold;}.di_section caption .basic_annotation{margin-top:0.5rem;}#di_table_3_1 th,#di_table_3_2 th{width:10em;vertical-align:middle;}#di_table_11_2 th{color:#58595b;}#di_table_11_2 tbody > tr > *{width:25%;text-align:left;vertical-align:top;font-weight:normal;}#di_table_11_2 .no_maker > li{display:inline;}#di_table_11_2 caption{caption-side:bottom;text-align:left;}@media screen and (max-width:768.98px){.di_section table{display:none;}}@media (min-width:769px){.pi_link_container{display:none;}}.red_line_block{padding:1rem;border:3px solid red;}.di_section > div.red_line_block > .explicit_maker > li > div:first-child,.di_section > div.red_line_block > .explicit_maker > li > div:last-child > h2{color:#58595b;}.lined_block_container{border:1px solid #58595b;padding:1rem;}.outline_list > dt{font-weight:bold;font-size:1.1rem;}.outline_list > dt::before{content:"\0FF1C";}.outline_list > dt::after{content:"\0FF1E";}.outline_list > .outline_list__title.--alter::before,.outline_list > .outline_list__title.--alter::after{content:none;}.outline_list > dt:nth-of-type(n + 2){margin-top:0.84rem;}.outline_list.start_with_mt{margin-top:0.84rem;}.contents_index_section{text-align:center;}.contents_index{list-style:none;font-size:0;padding:0;}.contents_index > ol{padding:0;}.contents_index li{display:inline-block;border-left:1px solid #58595b;border-right:1px solid #58595b;font-size:0.85rem;margin-left:-1px;padding:0 0.5rem;margin-bottom:0.5rem;}.contents_index_group dt{font-weight:bold;}.contents_index_group dt::before{content:"\03010";content:"\0FF1C";}.contents_index_group dt::after{content:"\03011";content:"\0FF1E";}.clinical_results__item_detail dt,.clinical_results__item_detail dd{display:inline-block;font-weight:bold;}.clinical_results__figure{padding:0;margin:2rem 0;}.clinical_results__figure.narrow_mb{margin-bottom:0.5rem;}.clinical_results__figure h3{color:#4d4084;font-size:1.1rem;border-left:5px solid #e7004c;line-height:1.6em;padding-left:0.5em;}.clinical_results__head-lv3{margin-top:2rem;color:#4d4084;font-size:1.1rem;border-left:5px solid #e7004c;line-height:1.6em;padding-left:0.5em;}.u-cl-main{color:#4d4084;}.clinical_results__figure picture{display:block;width:100%;max-width:800px;margin:1rem auto;}.clinical_results__figure picture > img{margin:0;}.patient_support_item_section a{flex-shrink:0;flex-grow:0;width:35%;max-width:250px;margin-left:1rem;}.patient_support_item_section a.horizontal{width:49%;max-width:352px;}.patient_support_item_section h3{color:#4d4084;font-size:1.1rem;border-left:5px solid #e7004c;line-height:1.6em;padding-left:0.5em;margin-top:0;}.patient_support_item_section a picture{width:100%;}.patient_support_item_section a picture img{width:100%;box-shadow:5px 5px 5px -3px rgba(0,0,0,0.1);}@media screen and (max-width:575.98px){.patient_support_item_section{flex-direction:column;margin-left:0;}.patient_support_item_section a{width:80%;margin:1rem auto 0;}.patient_support_item_section a.horizontal{width:90%;}.patient_support_item_section h3{font-size:1rem;}}.clinical_results__figure table,.clinical_results__figure table th,.clinical_results__figure table td{text-align:left;line-height:1.4em;font-weight:normal;}.clinical_results__figure table thead th{font-weight:bold;}.clinical_results__figure table:not(.non_100percent_table){width:100%;}.clinical_results__figure table th,.clinical_results__figure table td{padding:0.7rem 0.4rem 0.4rem 0.4rem;}.clinical_results__figure table thead th,.clinical_results__figure table tbody td{text-align:center;}th.helios_a{background-color:#f16f98;color:#ffffff;}th.apollo{background-color:#8390c8;color:#ffffff;}th.group_amvuttra{background-color:#e7004c;color:#ffffff;}th.group_patisiran{background-color:#3b3092;color:#ffffff;}th.group_all_amvuttra{background-color:#93d500;color:#ffffff;}th.group_placebo{background-color:#898a8d;color:#ffffff;}th.group_japanese{background-color:#f499bb;color:#ffffff;}#serum_ttr_concentration thead td,#serum_ttr_concentration tbody th{background-color:#dbe0e3;}.safety_content_section .colored_disc_maker > li:nth-of-type(n + 2){margin-top:1rem;}.safety_content_section .basic_annotation + .colored_disc_maker{margin-top:1rem;}.safety_content_section .colored_disc_maker > li::before{font-size:1.2rem;}.safety_content_section .colored_disc_maker > li > dl > dt,.safety_content_section > h2 + dl > dt{font-size:1.2rem;font-weight:bold;color:#4d4084;}.safety_content_section .colored_disc_maker .outline_list > dt,.safety_content_section > h2 + dl > dd{margin-top:1rem;}.with_indent_table > tbody > tr:not(.heading_line) > th{padding-left:1.5rem;}.with_indent_table > tbody > tr.heading_line > th:not(.non_bold){font-weight:bold;}@media screen and (max-width:575.98px){.clinical_results__figure table th,.clinical_results__figure table td{font-size:0.75rem;padding:0.5rem 0.3rem 0.4rem 0.3rem;}.with_indent_table > tbody > tr:not(.heading_line) > th{padding-left:0.5rem;}}.side_effect_overview > thead > tr:first-of-type > th{width:16rem;}.side_effect_overview thead td,.side_effect_overview tbody th{background-color:#e7eaec;}@media screen and (max-width:575.98px){.side_effect_overview tbody td{width:25%;}table sup{font-size:80%;}}#side_effect_list_1 > thead > tr:first-of-type > th{width:6rem;}#side_effect_list_2{margin-top:1rem;}caption.caption_side_bottom{caption-side:bottom;}#side_effect_list_2 .heading_line > *{background-color:#e7eaec;}#side_effect_list_1 thead tr,#side_effect_list_2 thead tr,#side_effect_list_3 thead tr{background-color:#bcc4c9;}@media screen and (max-width:575.98px){#side_effect_list_1 > thead > tr > th.group_amvuttra,#side_effect_list_1 > thead > tr > th.group_japanese,#side_effect_list_2 > thead > tr > th.group_amvuttra,#side_effect_list_2 > thead > tr > th.group_japanese{width:6em;}}.with_absolute_sup{position:relative;}.with_absolute_sup > sup{position:absolute;top:0.7em;right:-0.8em;}@media screen and (max-width:575.98px){.with_absolute_sup > sup{top:0.5em;right:-1em;}}.zero_padding{color:#ffffff;}.heading_line .zero_padding{color:#e7eaec;}.document{display:flex;padding:1rem 2rem;font-size:1.1rem;justify-content:space-between;align-items:flex-start;}@media screen and (max-width:575.98px){.document{padding:1rem 0;font-size:1rem;flex-direction:column;align-items:flex-end;}}.documents_section .document:first-of-type{border-top:2px solid #4d4084;}.documents_section .document:not(:last-of-type){border-bottom:1px solid #a5a0c0;}.documents_section .document:last-of-type{border-bottom:2px solid #4d4084;}.documents_section .document_name{font-weight:bold;flex-grow:0;flex-shrink:0;line-height:2rem;}@media screen and (max-width:575.98px){.documents_section .document_name{width:100%;}}.documents_section a{flex-grow:0;}@media screen and (max-width:575.98px){.documents_section a{margin-top:0.5rem;}}.documents_section .package_thumbnail{width:40%;position:relative;}@media screen and (max-width:575.98px){.documents_section .package_thumbnail{width:100%;}}.documents_section .package_thumbnail img{width:100%;}.documents_section .document_download{display:flex;align-items:center;line-height:2rem;}.documents_section .document_download::before{content:"";width:2rem;height:2rem;margin-right:0.5rem;background-image:url(/themes/amvuttra_jp/assets/image/download_icon.svg);background-size:contain;background-repeat:no-repeat;}.document.disabled .document_name{color:#bbb;}.document.disabled .document_download{color:#bbb;cursor:default;}.document.disabled .document_download:hover{opacity:1;text-decoration:none;}.documents_section .document.disabled .document_download::before{filter:grayscale(100%) opacity(40%);}#code_information table,#code_information table th,#code_information table td{font-size:1.1rem;font-weight:normal;text-align:left;}@media screen and (max-width:575.98px){#code_information table,#code_information table th,#code_information table td{font-size:0.9rem;}}#code_information table{width:100%;}#code_information table caption{caption-side:bottom;text-align:left;}#code_information table th,#code_information table td{padding:1rem 2rem;border-color:#a5a0c0;line-height:2rem;}#code_information table tr.disabled th,#code_information table tr.disabled td{color:#bbb;}@media screen and (max-width:575.98px){#code_information table th,#code_information table td{padding:1em 1em 1em 0;line-height:1.2rem;}#code_information table td,#code_information table tbody > tr:nth-of-type(4) > th:last-of-type,#code_information table tbody > tr:nth-of-type(5) > th:last-of-type{padding-left:1em;}}#code_information table > tbody > tr:first-of-type > *{border-top-width:2px;border-top-color:#4d4084;}#code_information table{border-bottom-width:2px;}@media (min-width:576px){#code_information table th{white-space:nowrap;font-weight:bold;width:1em;}}#code_information table th[rowspan]{white-space:nowrap;width:1em;}#code_information table tr > *:first-child{border-left:none;}#code_information table tr > *:last-child{border-right:none;}#code_information td.barcode img{width:200px;height:auto;margin:0;}.sitemap_section ul{padding:0 0 0 3rem;margin:0;}.sitemap_section li{margin:1rem 0;}.sitemap_section .sitemap_link{font-weight:bold;color:#4d4084;}.sitemap_section .sitemap_item > p{font-weight:bold;margin:0;}.sitemap_section .sitemap_item.group_title{list-style:none;padding:0;margin-left:-3rem;}.sitemap_section .sitemap_item.disabled > p{color:#bbb;}.pi_citation{background-color:#ffffff;border-radius:5px;box-shadow:0 0 10px 0 rgba(0,0,0,0.2);padding:1.5rem;margin-left:0;margin-right:0;}.proper_use_section .di_section{margin-bottom:1rem;}.proper_use_section .di_section > div > .explicit_maker > li > div:first-child,.proper_use_section .di_section > div > .explicit_maker > li > div:last-child > h2{color:#58595b;}.proper_use_section dl > dt{font-weight:bold;color:#4d4084;}.proper_use_section dl{margin-bottom:0.5rem;}#briefing p + ul{margin-top:0.5rem;}.proper_use_section ul li:last-of-type > dl{margin-bottom:0;}.proper_use_section .pi_citation + ul{margin-top:1.5rem;}.clinical-results-safety .pi_citation,.clinical-results-overview .pi_citation,.clinical-results-safety-helios-b .pi_citation,.clinical-results-overview-helios-b .pi_citation{background-color:#ffffff;border-radius:0;box-shadow:none;padding:0.5rem;margin-left:0;margin-right:0;border:1px solid #58595b;}.clinical-results-safety .pi_citation .di_section *,.clinical-results-overview .pi_citation .di_section *,.clinical-results-safety-helios-b .pi_citation .di_section *,.clinical-results-overview-helios-b .pi_citation .di_section *{font-size:1rem !important;margin-bottom:0 !important;}.belt_shaped_content{background-color:#f3f3f7;position:relative;z-index:110;padding:2rem 0;}.belt_shaped_content.belt_shaped_content_narrow_width{padding-left:10%;padding-right:10%;}.belt_shaped_content *{z-index:120;}.belt_shaped_content .patient_support_item_section_container p{color:#4d4084;}.belt_shaped_content::before{content:"";position:absolute;top:0;left:calc(-1 * (100vw - 100%) / 2);background-color:#f3f3f7;width:100vw;height:100%;z-index:100;}.patient_support_item_section.belt_shaped_content{margin-left:0;}@media (min-width:576px){.patient_support_item_section.belt_shaped_content a{width:25%;max-width:180px;}}#figure__flowchart{max-width:750px;}#figure__dosing_interval{max-width:550px;}#figure__dosing_interval figcaption{font-weight:bold;text-align:center;color:#000000;margin-bottom:0.5rem;}#figure__structure_and_name{max-width:650px;}div.attention_box{display:block;background:#f3f3f7;padding:0.5rem;}.dosing_step_figure_container{display:flex;align-items:flex-start;justify-content:space-between;width:100%;}.dosing_step_figure_container__left_column{flex-grow:1;}.dosing_step_figure_container__right_column{width:35%;min-width:250px;margin:0 0 0 2rem;padding:0;flex-grow:0;flex-shrink:0;display:flex;}.dosing_step_figure_container__right_column img{border-radius:10px;box-shadow:0px 0px 5px 1px rgba(0,0,0,0.1);}.dosing_step_figure_container + .dosing_step_figure_container{margin-top:1rem;}.figure_name{color:#4d4084;font-weight:bold;}.related_materials_container{display:flex;align-items:flex-start;justify-content:space-around;}.related_materials_container a{width:100%;max-width:400px;}@media (min-width:576px){.related_materials_container a:first-of-type{margin-right:0.8rem;}.related_materials_container a:last-of-type{margin-left:0.8rem;}}.related_materials_container a .figure{display:block;margin:0;padding:0;}.related_materials_container a img{margin:0;border-radius:5px;width:100%;}.related_materials_container a picture{display:block;margin-bottom:0.5rem;position:relative;}.related_materials_container a.popup_video picture::before{position:absolute;left:10px;bottom:10px;background-color:#e7004c;content:"";width:40px;height:40px;border-radius:20px;z-index:121;}.related_materials_container a.popup_video picture::after{position:absolute;content:"";left:24px;bottom:18px;border-top:12px solid transparent;border-bottom:12px solid transparent;border-left:16px solid #ffffff;z-index:122;}.related_materials_container a .figcaption{display:block;color:#4d4084;font-weight:bold;}#videoplayerModal .embed-responsive{width:100%;}#videoplayerModal .modal-dialog{padding:3rem 1rem 1rem 1rem;}@media screen and (max-width:575.98px){#videoplayerModal .modal-dialog{padding:3rem 0 0 0;}}#videoplayerModal .modal-content-body{width:100%;margin:0;}#videoplayerModal .modal-content-message{display:none;}#videoplayerModal .button_confirm{position:absolute;box-sizing:border-box;right:0.5rem;top:0.5rem;width:2rem;height:2rem;border-radius:2rem;border:3px solid #4d4084;display:flex;justify-content:center;align-items:center;line-height:0;font-weight:bold;font-size:1.5rem;margin:0;padding:2px 0 0 0;}#videoplayerModal .button_confirm:hover{text-decoration:none;}#helios_a_method{max-width:850px;}#efficacy__chocardiographic figcaption{margin-top:3rem;}#safety_consideration_list h2{margin-bottom:0.5rem;font-size:1rem;color:#58595b;}#safety_consideration_list dl{display:grid;border-top:1px solid #4d4084;}#safety_consideration_list dl > *{padding:0.6rem;border:1px solid #4d4084;border-left:none;border-top:none;}#safety_consideration_list dt{color:#58595b;}#safety_consideration_list dt::before{content:"\03010";}#safety_consideration_list dt::after{content:"\03011";}@media (min-width:769px){#safety_consideration_list dl{grid-template-columns:repeat(3,1fr);}#safety_consideration_list dt{text-align:center;}#safety_consideration_list dl > *:nth-child(1){grid-column:1;grid-row:1;border-left:1px solid #4d4084;}#safety_consideration_list dl > *:nth-child(2){grid-column:1;grid-row:2;border-left:1px solid #4d4084;}#safety_consideration_list dl > *:nth-child(3){grid-column:2;grid-row:1;}#safety_consideration_list dl > *:nth-child(4){grid-column:2;grid-row:2;}#safety_consideration_list dl > *:nth-child(5){grid-column:3;grid-row:1;}#safety_consideration_list dl > *:nth-child(6){grid-column:3;grid-row:2;}}@media screen and (max-width:768.98px) and (min-width:576px){#safety_consideration_list dl{grid-template-columns:minmax(max-content,max-content) 1fr;}#safety_consideration_list dl > *:nth-child(1){grid-column:1;grid-row:1;border-left:1px solid 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